Blue marker dead space1/18/2024 Intermixed within these amyloids were a menagerie of membrane parts, including extracellular vesicles and lipid droplets, multilamellar bodies, and bits of plasma membrane. Cryo-ET exposed a mishmash of materials within plaques, including Aβ fibrils arranged in parallel bundles and lattices, along with short protofilament rods, some of which branched off from the fibrils. Previously, these researchers used similar methods to examine the in situ architecture of Aβ plaques within the brains of APP knock-in mice ( May 2023 news). “These new findings from the Frank lab inch us closer to understanding how the atomic structure of amyloid fibrils relates to the adjacent subcellular disturbances underlying dementia.” “The past several years of work from the labs of Michel Goedert and Sjors Scheres, among others, have shown us how the atomic structure of extracted fibrils correlates with histopathologic diagnosis,” wrote Andrew Stern and Dennis Selkoe of Brigham and Women’s Hospital in Boston (comment below).
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |